Statistik-Beratung ROC curve, ROC curves, DAC method, diagnostic studies


Welcome ! Deutsche Version Statistical services Design and analysis SAS® programming Statistical consulting Statistical training Topics: Diagnostics Diagnostic studies ROC curve ROC software tools Topics: Clin. Laboratory Method validation Topics: Software Download Web-Shop contact Presentation References Imprint


E. Meisel: Achilles und die Schildkröte (
disease cluster

You are at: References/Literature

ACOMED statistics: Publications of Dr. Thomas Keller

Literature                                   back to references

New: Keller T, Faye S, Katzorke T (2011): Statistical Test for Equivalence in Analysis of Method Comparison Experiments. Application in comparison of AMH assays. CCLM 49, S 806, Download Poster

New: Auclair G, Keller T, Sinha P, Sheldon J, Rota F, Schimmel H, Zegers I (2011): Commutability study on ERM-DA472/IFCC, C-reactive protein in human serum. CCLM 49, S804

New: Fillée1 C, Keller T, Ketelslegers JM (2011): Vitamin-D related parathyroid hormone reference ranges and their impact on the diagnosis of mild primary hyperparathyroidism. CCLM 49, S423

New: Katzorke T, Faye SA, Keller T (2011): AMH GEN II: A Comparison of results versus DSL AMH ELISA and reference interval data. CCLM 49, S421

New: Titiz I, Laubinger M, Keller T, Hertrich K and Hirschfelder U (2011): Repeatability and reproducibility of landmarks — a three-dimensional computed tomography study. Europ J Orthodontics, 10.1093/ejo/cjq190

Schuster FR, Hubner B, Führer M, Eckermann O, Gombert M, Dornmair K, Binder V, Reuther S, Krell P, Keller T and Borkhardt A (2011): Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia. BCJ 1, e8; doi:10.1038/bcj.2011.6

Zegers I, Keller T, Schreiber W, Sheldon J, Albertini R, Blirup-Jensen S, Johnson M, Trapmann S, Emons H, Merlini G, Schimmel H (2010): Characterisation of ERM-DA470k/IFCC for 12 serum proteins. Clin Chem, 56:1880-1888

Zemlin AE, Essack Y, Rensburg M, Keller T, Brinkmann T (2010): Stability of Red Blood Cell Folate in Whole Blood and Haemolysate. Clin. Lab 56: 391-396

Keller T, Brinkmann T (2010): Statistical Test for Equivalence and Non-Inferiority in Analysis of Method Validation and Comparison Experiments: Application in Assessment of Carry-over. Clin Chem; 56 Suppl.: A222

Jung R, Jacobs U, Krumbholz M, Langer T, Keller T, De Lorenzo P, Valsecchi MG, van der Velden VH, Moericke M, Stanulla M, Harbott J, Panzer-Grumayer , van Dongen JJM, Pieters R, Schrappe M, Rascher W, Metzler M (2010): Bimodal distribution of genomic MLL breakpoints in infant acute lymphoblastic leukemia, Leukemia 24:903-907

Denton KJ, Bergeron C, Klement P, Trunk MJ, Keller T, Ridder R (2010): The sensitivity and specificity of p16INK4a Cytology versus HPV Testing for Detecting High-Grade Cervical Disease in the Triage of ASC-US and LSIL Pap Cytology Results. Am J Clin Pathol 134:12-21

Bergeron C, Ordi J, Schmidt D, Trunk MJ, Keller T, Ridder R (2010): Conjunctive p16INK4a Testing Significantly Increases Accuracy in Diagnosing High-Grade Cervical Intraepithelial Neoplasia. Am J Clin Pathol 133:395-406

Weber S, Keller T (2009): Statistical Analysis of Commutability Experiments: Application of equivalence test as an advantageous approach. CCLM 47, A22. Download Poster

Keller T, Weber S (2009): Statistical Test for Equivalence in Analysis of Commutability Experiments. CCLM 47, 376-377. Download Poster

Keller T, Brinkmann T (2009): Statistical Test for Equivalence and Noninferiority in Analysis of Method Validation and Comparison Experiments. Application in Assessment of Carry-Over. CCLM 47, 356-357. Download Poster

von Goessel H, Jacobs U, Semper S, Krumbholz M, Langer T, Keller T, Schrauder A, van der Velden VHJ, van Dongen JJM, Harbott J, Panzer-Grümayer ER, Schrappe M, Rascher W, Metzler M (2008): Cluster analysis of genomic ETV6-RUNX1 (TEL-AML1) fusion sites in childhood acute lymphoblastic leukemia. Leuk Res 33(8): 1082-81

Busch K, Keller T, Fuchs U, Yeh R-F, Harbott J, Klose I, Wiemels J, Novosel A, Reiter A and Borkhardt A (2007): Identification of two distinct MYC breakpoint clusters and their association with various IGH breakpoint regions in the t(8;14) translocations in sporadic Burkitt-lymphoma. Leukemia 21(8): 1739-51

Rombaux P, Bertrand B, Keller T, Mouraux A (2007): Clinical Significance of Olfactory Event- Related Potentials Related to Orthonasal and Retronasal Olfactory Testing. Laryngoscope, 117:1096–1101.

Schmerbach KI, Boeltzig CKM, Reif U, Wieser JC, Keller T, Grevel V (2007): In Vitro Comparison of Tibial Plateau Leveling Osteotomy with and Without Use of a Tibial Plateau Leveling Jig. Vet. Surg. 36: 156-163.

Keller T : Statistische Aspekte bei der Multiparameteranalyse. In: Sack U, Tárnok A, Rothe G (Hrsg.): Zelluläre Diagnostik. Grundlagen, Methoden und klinische Anwendungen der Durchflusszytometrie. Karger Basel, Freiburg (2007), 208-236

Sack U, Biereder B, Elouahidi T, Bauer K, Keller T, Trobs RB (2006): Diagnostic value of blood inflammatory markers for detection of acute appendicitis in children. BMC Surg. 28, 6-15.

Jung K, Lein M, Butz H, Stephan C, Loening SA, Keller T (2006): New Insights into the Diagnostic Accuracy of Complexed and Total Prostate Specific Antigen Using Discordance Analysis Characteristics. Urology 175, 1275-1280

Müller V, Witzel I, Pantel K, Krenkel S, Lück HJ, Neumann R, Keller T, Dittmer J, Jänicke F, Thomssen C (2006): Prognostic and Predictive Impact of Soluble Epidermal Growth Factor Receptor (sEGFR) Protein in the Serum of Patients Treated with Chemotherapy for Metastatic Breast Cancer. Anticancer Res. 26, 1479-1488

Keller T, Butz H, Lein M, Kwiatowski M, Semjonow A, Luboldt H-J, Hammerer P, Stephan C, Jung K (2005): Discordance Analysis Characteristics (DAC) as a New Method to Compare the Diagnostic Accuracy of Tests: the Example of Complexed Versus Total Prostate-Specific Antigen. Clin Chem 51, 532-539

Heiss C, Hoesel LM, Wehr U, Keller T, Horas U, Meyer C, Rambeck W, Schnettler R (2004): Vitamin K in combination with other biochemical markers to diagnose osteoporosis. Biomarkers 9, 479-488

Heiss C, Keller T, Wehr U, Mohr A, Lommel D, Meyer Ch, Rambeck WA, Schnettler R (2004): Biochemical Markers and their Significance in Postmenopausal Osteoporosis - A new Method in the Diagnosis of Osteoporosis? Biomed Technik 49: 262-268s

Wilda M, Busch K, Klose I, Keller T, Woessmann W, Kreuder J, Harbott J, Borkhardt A (2004): The level of MYC overexpression in pediatric Burkitt´s lymphoma is strongly dependent on the genomic breakpoint location within the MYC locus. Genes, Chromosomes & Cancer 41:178-82

Heiss C, Keller T, Wehr U, Pausch M, Horas U, Kilian O, Rambeck WA, Schnettler R (2003): The Assessment of Biochemical Marker Profiles in Diagnosis of Osteoporosis (in german). Akt Rheumatol 28: 164-171

Busch K, Keller T, Klose I, Harbott J, Reiter A and Borkhardt A (2003): Distribution of genomic breakpoints in children with Burkitt´s Lymphoma/ Leukemia (Poster). J Ped Haematol Oncol 25(4): S16-S17

Nuber A, Keller T, Bitterlich N, Gillissen A, Leonhardt P (2002): Diagnosis And Monitoring Of Therapy Of Lung Cancer With A Tumor Marker Profile: Comparing CYFRA 21-1, CEA And NSE With Fuzzy Logic-Based Tumor Marker Profiles. 98th International Conference of the American Thoracic Society, May 17-22, Atlanta, Band of Abstracts, p. A48

Keller T (2001): (invited lecture) Enhancing clinical value of tumor markers with Fuzzy Logic. XXIX meeting of International Society for Oncodevelopmental Biology and Medicine (ISOBM), Barcelona, sept. 29th - oct. 3rd , 2001, Band of abstracts, p. SS20

Keller T (2000): (invited lecture) Fuzzy logic approach for enhancing the diagnosis of cancer. XXVIII meeting of International Society for Oncodevelopmental Biology and Medicine (ISOBM) Munich, 2000, Tumor Biology 21 S1: 15

Halm U, Rohde N, Klapdor R, Reith HB, Thiede A, Etzrodt G, Mossner J, Keller T (2000): Improved sensitivity of fuzzy logic based tumor marker profiles for diagnosis of pancreatic carcinoma versus benign pancreatic disease. Anticancer Res. ; 20:4957-60

Keller T, Bigl H, Löser T, Leonhardt P (1998):Neue Möglichkeiten der Tumormarker-Diagnostik des Bronchialkarzinoms mittels fuzzy-basierter Auswertung von Tumormarkerprofilen (Poster). Pneumologie; 52: S33

Keller T, Bitterlich N, Hilfenhaus S, Bigl H, Löser T, Leonhardt P (1998): Tumour markers in the diagnosis of bronchial carcinoma: new options using fuzzy logic based tumour marker profiles. J Cancer Res Clin Oncol 124: 565-574

Keller T, Gehring L, Löser T (1998): Spurenelementverschiebungen bei Patienten mit chronischem Nierenversagen unter Dialyse. Nieren- und Hochdruckkrankheiten 27: 522-532

Lipp T, Lipp I, Keller F, Wolff F, Keller T (1994): Neue Aussagen zum Harnsteinleiden aus statistischer Sicht. Zeitschr. f. 17: 42

Pissarek P, Jähnichen F, Blasig IE, Haseloff R, Keller T, Tapp E, Krause E-G (1995): Cardioprotective potency of the radical scavenger S-2-(3 aminopropylamino) ethylphosphorothioic acid in the post-ischemic rat heart. Mol Cell Biochem. 145: 121-9

ROC curve, ROC curves, DAC method
Copyright: ACOMED   
{short description of image}
{short description of image} {short description of image} {short description of image}